TOXICOLOGY

英文简介

Toxicology is a journal for the publication of original scientific papers on the biological effects arising from the administration of chemical compounds, principally to animals, tissues or cells, but also to man. Such compounds include industrial chemicals and residues, chemical contaminants, consumer products, drugs, metals, pesticides, food additives, cosmetics, and additives to animal feedstuff. Preference will be given to investigations dealing with the mechanisms of action of toxic agents. Papers describing molecular interactions with cellular and genetic processes will be welcomed.Quantitative toxicological studies will be published that are of relevance to risk assessment and regulatory management of exposure hazards and safety evaluation. This applies particularly to carcinogenicity, mutagenicity, embryotoxicity and related areas, as well as to alternatives to the use of animals in toxicological experimentation. Epidemiological studies bearing toxicological significance to man fall within the scope of the journal. The Editors also welcome the submission of concise and pertinent reviews on current issues in toxicology.IMMUNOTOXICOLOGY, a section of the journal, includes original papers and peer reviews dealing with any adverse interference of chemicals, including drugs, with the immune system: immunosuppression, hypersensitivity, auto-immunity, immune-mediated side-effects of drugs, toxicity of immunomodulating and immunotherapeutic agents. ENVIRONMENTAL AND NUTRITIONAL INTERACTIONS: A new section dedicated to original research and comprehensive critical reviews of animal as well as human and computer modeling studies of the interactions between the environment and nutrition. These include the effects of environmental changes on nutrition and food production; identification of nutrient interactions with environmentally induced disorders; the effect of nutritional status on the response to environmental stresses; and understanding the mechanisms of such interactions and their impact on human health and welfare. A list of forthcoming manuscripts is available on Internet via http://www.elsevier.nl/locate/toxicol-manuscripts.

中文简介

《毒理学》是一本发表有关化学化合物（主要是对动物、组织或细胞，也包括对人）的生物效应的原始科学论文的杂志。这些化合物包括工业化学品和残留物、化学污染物、消费品、药物、金属、农药、食品添加剂、化妆品和动物饲料添加剂。将优先考虑调查有毒物质的作用机制。将欢迎描述分子与细胞和遗传过程相互作用的论文。将发表定量毒理学研究，这些研究与风险评估、暴露危险的监管管理和安全性评估有关。这尤其适用于致癌性、致突变性、胚胎毒性和相关领域，以及毒理学实验中动物使用的替代品。对人类具有毒理学意义的流行病学研究属于该杂志的范围。编辑们也欢迎就毒理学的当前问题提交简洁而有针对性的评论。免疫毒理学是该杂志的一个部分，它包括原始论文和同行评论，涉及化学物质（包括药物）对免疫系统的任何不良干扰：免疫抑制、超敏反应、自身免疫、免疫介质。药物的副作用，免疫调节剂和免疫治疗剂的毒性。环境与营养相互作用：一个新的领域，致力于对动物的原始研究和全面的批判性评论，以及对环境与营养相互作用的人类和计算机建模研究。其中包括环境变化对营养和食品生产的影响；识别营养与环境引起的疾病的相互作用；营养状况对环境压力反应的影响；理解这种相互作用的机制及其对人类健康和福利的影响。即将出版的手稿列表可通过http://www.elsevier.nl/locate/toxicol-manipscripts在互联网上查阅。

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