JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

英文简介

The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental or theoretical developments in areas related to steroids. It publishes original papers as well as general and mini-reviews, proceedings of selected meetings and rapid communications (brief highly-topical articles of particular interest).The journal covers a wide range of topics relating to steroids:- Molecular, cellular, and physiological actions of steroid hormones, steroid anti-hormones and their analogs via regulation of gene expression or other mechanisms. Structure, function, regulation, and cell biology of receptors of the steroid-thyroid-retinoid superfamily. Cross-talk between steroids, steroid receptors and other signal transduction pathways. Steroids and cell proliferation, regulation of cell cycle genes. Steroid transport. Steroids and cancer: functional relationships in normal and neoplastic tissues between steroid hormones and cytokines, growth factors, growth inhibitors, and oncogenes. Steroids and cancer prevention. Biosynthesis, secretion, and metabolism of steroids and of biologically-related compounds, and their regulation by peptide hormones, prostaglandins and other substances. Molecular aspects of enzymes involved in steroidogenesis. Novel therapeutic applications of new steroid agonists or antagonists. Steroids and neuroendocrinology or neuroimmunology. Neurosteroids, steroid action on synactic transmission and modulation. Steroid hormones and hypertension. Steroids and their actions on bone and on the cardiovascular systems. Steroid enzyme inhibitors. Steroids and analogs in menopause. Steroids in hormone replacement therapy. Steroid hormones in osteoporosis: basic and clinical applications. Steroids and contraception. Defects in steroid metabolism. Steroid hormones during pregnancy, development and sex differentiation. Structure, physicochemical, chemical and pharmacological characteristics of natural and synthetic steroids and related compounds of biological interest. Innovative techniques relating to steroids and biologically-related substances. Clinical and physiological studies of inborn or acquired changes of biosynthesis, metabolism or action of steroids and their receptors. Comparative endocrinology and evolution of steroids. Environmental effects on steroid metabolism and action.

中文简介

甾体生物化学和分子生物学杂志致力于甾体相关领域的新的实验或理论发展。它出版原始论文以及一般和小型评论、选定会议的记录和快速通讯(特别感兴趣的高度专题的简要文章)。该杂志涵盖了广泛的主题有关类固醇:分子，细胞，和生理活动的类固醇激素，类固醇抗激素及其类似物通过调控基因表达或其他机制。甾体-甲状腺-维甲酸超家族受体的结构、功能、调控及细胞生物学。甾体、甾体受体及其他信号转导途径的交叉对话。类固醇与细胞增殖，调节细胞周期基因。类固醇运输。类固醇与癌症:类固醇激素与细胞因子、生长因子、生长抑制因子及癌基因在正常及肿瘤组织中的功能关系。类固醇和癌症预防。类固醇和生物相关化合物的生物合成、分泌和代谢，以及它们受肽激素、前列腺素和其他物质的调节。参与类固醇生成的酶的分子方面。新型类固醇激动剂或拮抗剂的新治疗应用。类固醇和神经内分泌学或神经免疫学。神经甾体，甾体对合乳酸传递和调节的作用。类固醇激素和高血压。类固醇及其对骨骼和心血管系统的作用。类固醇酶抑制剂。更年期类固醇和类似物。激素替代疗法中的类固醇。类固醇激素在骨质疏松症:基础和临床应用。类固醇和避孕。类固醇代谢缺陷。类固醇激素在怀孕期间，发育和性别分化。天然和合成类固醇及其相关生物活性化合物的结构、理化、化学和药理特性。类固醇和生物相关物质的创新技术。类固醇及其受体的生物合成、代谢或作用的先天或后天变化的临床和生理学研究。比较内分泌学和类固醇的进化。环境对类固醇代谢和作用的影响。

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