Disease Models & Mechanisms

英文简介

Disease Models & Mechanisms (DMM) publishes original research, resources and invited reviews that focus on the use of model systems to better understand, diagnose and treat human disease. The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting highly significant research that meets this goal. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its scope.Examples of DMM content:Basic research that significantly advances our understanding of human disease mechanisms, diagnosis or treatment, and is of broad relevanceDrug screens and preclinical analyses of candidate therapies using model systemsPresentation of new models that have been thoroughly validated to demonstrate their utility in disease studies* New methods and resources that provide broadly useful tools for a disease and/or model communityComprehensive, expert reviews and posters addressing current and emerging themes in biomedical scienceInterviews with leading scientists in translational researchEditorials that discuss wider issues of interest to the community, including regulatory, ethical and policy issuesSpecial collections that collate articles relating to a particular disease area or model system *Descriptive work, such as the characterisation of a model system without demonstration of its usefulness to advance a field, is generally not considered for publication, unless the new model itself is considered by the Editorial team to provide an improved understanding of the disease mechanism and/or to demonstrate clear usefulness for the evaluation of treatment approaches. Model systems of interest include:Vertebrates such as mice, zebrafish, frogs, rats and other mammalsInvertebrates such as Drosophila melanogaster and Caenorhabditis elegans Unique in vitro or ex vivo models, such as stem-cell-based models, organoids and systems based on patient materialMicroorganisms such as yeast and DictyosteliumOther biological systems with relevance to human disease researchDisease areas of interest include:CancerNeurodegenerative and neurological diseasesPsychiatric disordersMetabolic disorders, including diabetes and obesityCardiovascular diseases, stroke and hypertensionGastrointestinal diseasesInfectious diseasesAutoimmunity and inflammationDevelopmental diseasesMusculoskeletal disordersRenal or liver diseaseEye disordersDrug and biomarker discovery/screeningStem cells therapies in regenerative medicine

中文简介

疾病模型与机制（DMM）发布了最初的研究、资源和邀请评论，重点是使用模型系统更好地理解、诊断和治疗人类疾病。DMM的主要目的是通过促进基础研究人员和临床研究人员在转化科学方面的合作来促进人类健康。该杂志致力于提出符合这一目标的非常重要的研究。DMM的跨学科性质意味着各种各样的疾病、方法和模型都在其范围内。DMM内容示例：显著促进我们对人类疾病机制、诊断或治疗的理解的基础研究，具有广泛的相关性。使用模型系统的候选疗法的药物筛选和临床前分析介绍经过彻底验证的新模型，以证明其在疾病研究中的实用性。*为疾病和/或示范社区提供广泛有用工具的新方法和资源针对生物医学科学中当前和新兴主题的全面、专家评论和海报翻译研究领域的主要科学家访谈讨论更广泛的社会关注问题的社论，包括监管、伦理和政策问题整理与特定病区或模式系统有关的文章的特别收藏*一般不考虑出版说明性的工作，例如说明一个示范系统的特点，而不表明其对促进某一领域的作用，除非编辑小组考虑到新的模式本身，以便更好地了解疾病的机制和(或)证明对评价治疗方法有明确的用处。感兴趣的模型系统包括：脊椎动物，如小鼠、斑马鱼、青蛙、大鼠和其他哺乳动物无脊椎动物，如黑腹果蝇和秀丽隐杆线虫独特的体外或体外模型，如基于干细胞的模型、基于患者材料的器官和系统微生物，如酵母和盘基网柄菌其他与人类疾病研究有关的生物系统感兴趣的疾病领域包括：癌症神经退行性疾病和神经系统疾病精神疾病代谢紊乱，包括糖尿病和肥胖心血管疾病、中风和高血压胃肠道疾病传染病自身免疫和炎症发育性疾病肌肉骨骼疾病肾脏或肝脏疾病眼部疾病药物和生物标志物的发现/筛选再生医学中的干细胞疗法

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